Delirium is a serious neurocognitive disorder experienced by approximately 25% of older adults after popular cardiac procedures. It is characterised by acute and fluctuating disturbances in attention, arousal, and cognition; with consequences including 2-5 fold increased dementia risk, higher mortality and risk of cognitive impairment. Functional connectivity between brain regions are a requirement of cognition and consciousness, and whilst it is hypothesised that breakdown in connectivity precedes delirium, there is little supporting empirical data. Therefore, my PhD will use electroencephalogram (EEG) functional connectivity and other EEG measures including mismatch negativity to predict delirium presence and severity in older patients undergoing coronary artery bypass grafting (CABG) and transcatheter aortic valve implantation (TAVI).
Supervisors: A/Prof Hannah Keage and Dr Bahar Moezzi